' 
![]()
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.5
USERS' SCORE
Good
Based on 12 Reviews
8.6
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Folate [as (6S)-5-Methyltetrahydrofolate, Calcium salt]
1,700 mcg○
425%
Top Medical Research Studies
9
Folic acid reduces CHD risk
Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.
Study directly links folate to heart health
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Read More
8
Folate levels impact heart disease
Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring.
High relevance to heart disease
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Read More
9.5
Folate's role in heart protection
Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder.
Focus on folate for TDD
We explored the effects of folate, a form of vitamin B, on heart problems associated with TANGO2-deficiency disorder (TDD). This genetic condition can lead to dangerous heart rhythms that don’t respond well to standard treatments. To dive deeper into this issue, we established patient-derived heart cells, known as iPSC-CMs, to mimic the heart abnormalities seen in TDD.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
Read More
Most Useful Reviews
8.8
Supports cellular health
Having researched dietary supplements, I can say that Optimized Folate 1700 mcg DFE is impressive. It’s highly bioavailable, helps with amino acid metabolism, and supports cardiovascular health by regulating homocysteine levels. I take one capsule daily with no side effects.
Read More
9.5
Great for heart health
Great Supplement for Heart Health.
Read More
9.5
Lowers homocysteine levels
This is a no-brainer! Folic acid has numerous benefits. I take it to manage my homocysteine levels, which have been associated with heart disease and strokes. Given my history, I believe taking folate is wise.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.5
9.5
Folate's role in heart protection
Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder.
Focus on folate for TDD
We explored the effects of folate, a form of vitamin B, on heart problems associated with TANGO2-deficiency disorder (TDD). This genetic condition can lead to dangerous heart rhythms that don’t respond well to standard treatments. To dive deeper into this issue, we established patient-derived heart cells, known as iPSC-CMs, to mimic the heart abnormalities seen in TDD.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
Read More
9
Folic acid reduces CHD risk
Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.
Study directly links folate to heart health
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Read More
8
Folate may reduce heart defect risks
Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study.
High relevance to maternal health
In our exploration of the connection between heart health and maternal nutrition, we focused on the role of folate and multivitamin supplements during pregnancy. We investigated how these supplements might help combat the risks posed by total volatile organic compounds (TVOCs)—harmful indoor air pollutants—on developing babies.
We conducted a case-control study involving pregnant women at different stages of gestation, gathering data on their supplement intake, measuring important nutrients in their blood, and assessing their exposure to indoor air pollutants. Our analysis revealed a concerning link between high indoor TVOC levels and increased rates of congenital heart disease (CHD) in newborns.
Excitingly, we found that regular intake of multivitamins, including folate, could help alleviate these risks. This suggests that ensuring proper nutrient intake could be a simple yet effective strategy for expectant mothers living in environments with high indoor pollution levels. Overall, our findings underline the potential protective benefits of folate and a well-balanced diet in promoting heart health for the next generation.
We conducted a case-control study involving pregnant women at different stages of gestation, gathering data on their supplement intake, measuring important nutrients in their blood, and assessing their exposure to indoor air pollutants. Our analysis revealed a concerning link between high indoor TVOC levels and increased rates of congenital heart disease (CHD) in newborns.
Excitingly, we found that regular intake of multivitamins, including folate, could help alleviate these risks. This suggests that ensuring proper nutrient intake could be a simple yet effective strategy for expectant mothers living in environments with high indoor pollution levels. Overall, our findings underline the potential protective benefits of folate and a well-balanced diet in promoting heart health for the next generation.
Read More
8
Folate levels impact heart disease
Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring.
High relevance to heart disease
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Read More
8
Folate improves heart disease outcomes
MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis.
Folate's role in heart disease
We investigated how folate treatment, particularly in the presence of specific genetic variations, impacts patients with heart disease and hypertension. The study included 540 individuals diagnosed with coronary heart disease, categorized into three groups based on their treatment: those receiving folic acid, those without it, and a control group with standard treatment.
We discovered that patients who received folic acid along with enalapril showed a significantly lower recurrence rate of cardiovascular events compared to those who did not receive folic acid. Furthermore, the group treated with folic acid exhibited improved cholesterol levels, indicating better heart health outcomes.
Importantly, we noted that a significant portion of the patients possessed the MTHFR C677T gene mutation, potentially impacting their response to treatment. Overall, our findings suggest that folic acid supplementation plays a crucial role in enhancing the treatment effects for patients with coronary heart disease, particularly for those at higher risk due to their genetic background.
By combining gene screening and folic acid treatment, we can potentially improve clinical outcomes in a population that often struggles with managing heart-related issues effectively.
We discovered that patients who received folic acid along with enalapril showed a significantly lower recurrence rate of cardiovascular events compared to those who did not receive folic acid. Furthermore, the group treated with folic acid exhibited improved cholesterol levels, indicating better heart health outcomes.
Importantly, we noted that a significant portion of the patients possessed the MTHFR C677T gene mutation, potentially impacting their response to treatment. Overall, our findings suggest that folic acid supplementation plays a crucial role in enhancing the treatment effects for patients with coronary heart disease, particularly for those at higher risk due to their genetic background.
By combining gene screening and folic acid treatment, we can potentially improve clinical outcomes in a population that often struggles with managing heart-related issues effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.6
9.5
Reduces homocysteine levels
My doctor recommended I take 5-MTHF due to my family's high homocysteine levels, linked to heart disease. After three days of taking it, I've been sleeping soundly.
9.5
Great for heart health
Great Supplement for Heart Health.
9.5
Lowers homocysteine levels
This is a no-brainer! Folic acid has numerous benefits. I take it to manage my homocysteine levels, which have been associated with heart disease and strokes. Given my history, I believe taking folate is wise.
8.8
Improves folate levels
On Iherb, there are many good folates, and this is one of them. I’m ordering a third package from different brands! It’s an ideal formula for folate for those planning a pregnancy, suffering from anaemia or elevated homocysteine levels, which is a marker of cardiovascular diseases! I recommend it!
Read More
8.8
Enhances cardiovascular health
L-Methylfolate is a bioactive form of folate that absorbs easily. Low folate increases homocysteine levels, leading to early ageing and cardiovascular disease. For those with folate cycle mutations, methylfolate effectively addresses deficiencies.
